Hi,
This is just information about a large conceptual change which is
about to occur in one of the dispersion models. The 'MQ NS CPMG
2-site' model will soon change name. This is the model implementing
Dmitry Korzhnev's numeric solution in his first 2004 JACS paper:
Korzhnev, D. M., Kloiber, K., Kanelis, V., Tugarinov, V., and Kay,
L. E. (2004). Probing slow dynamics in high molecular weight proteins
by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme.
J. Am. Chem. Soc., 126(12), 3964–3973.
(http://dx.doi.org/10.1021/ja039587i).
This model will soon be modified to handle the 1H SQ, 15N SQ, ZQ, DQ,
1H MQ and 15N MQ CPMG dispersion data simultaneously. I.e. it will be
the logical extension to Dmitry's 2005 JACS paper:
Dmitry M. Korzhnev, Philipp Neudecker, Anthony Mittermaier,
Vladislav Yu. Orekhov, and Lewis E. Kay (2005) Multiple-site exchange
in proteins studied with a suite of six NMR relaxation dispersion
experiments: An application to the folding of a Fyn SH3 domain mutant.
127, 15602-15611 (doi: http://dx.doi.org/10.1021/ja054550e).
The new model name will be 'MMQ 2-site', where MMQ stands for
multi-multiple quantum for lack of a better name.
Regards,
Edward
Support for combined proton-heteronuclear SQ, ZQ, DQ, and MQ CPMG data in the dispersion analysis.