Ever since the original Lipari and Szabo papers (Lipari and Szabo, 1982a,b), the question of how to obtain the modelfree description of the system has followed the route in which the diffusion tensor is initially estimated. Using this rough estimate, the modelfree models are optimised for each spin system i, the best model selected, and then the global model of the diffusion model with each modelfree model is optimised. This procedure is then repeated using the diffusion tensor parameters of as the initial input. Finally the global model is selected. The full protocol, when combined with AIC model selection (d'Auvergne and Gooley, 2003), is illustrated in Figure 7.2.

Again this protocol is not implemented in the relax sample scripts. This would have to be implemented in exactly the same manner as described in the previous section, but using the AIC model selection build into relax. Constructing this set of scripts, or a single master script, would be much easier than the Mandel et al. (1995) protocol as Modelfree4 would not need to be used, and the handling of Ftests and chisquared tests is avoided.
The relax user manual (PDF), created 20190308.